库纳吉、薰和谷西三人踏上紧张的逃亡之路，躲避未知的袭击。原来他们在被大批猫咪无情追杀！一种由病毒引起的猫瘟在全世界蔓延，这种病毒会把所有接触过猫的人变成猫。谷西被成群的猫追上并围攻，变成了一只可爱的猫咪。伙伴们共同经历了喵病爆发后的一切，并肩作战，最终找到了人类与猫和平相处的方式，也开始了新的旅程。
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